Histone Deacetylases and their Inhibitors as Potential

treatment regimen is still an unmet need. This might lead to the fact that few CCA patients are suitable for the surgery as well as the limitation of other therapeutic modalities (Patel, 2006; Sia et al., 2013; Zabron et al., 2013). In addition, the palliative chemotherapy and radiotherapy have been used as adjuvant therapy for this cancer type. Various chemotherapeutic agents e.g. 5-fluorouracil (5-FU), gemcitabine, and cisplatin, either alone or in combination, have been widely used in CCA (Hejna et al., 1998; Khan et al., 2002; Thongprasert, 2005). However, the previous clinical studies have demonstrated that chemotherapeutic response rate of CCA is relatively poor Abstract